Evaluating the role of MEN1 gene expression and its clinical significance in breast cancer patients.

ABSTRACT:

Background

Breast cancer is a multifactorial disease which involves number of molecular factors that are critically involved in proliferation of breast cancer cells. MEN1 gene that is traditionally known for its germline mutations in neuroendocrine tumors is associated with high risk of developing breast cancer in females with MEN1 syndrome. However, the paradoxical role of MEN1 is reported in sporadic breast cancer cases. The previous studies indicate the functional significance of MEN1 in regulating breast cells proliferation but its relevance in development and progression of breast cancer is still not known. Our study targets to find the role of MEN1 gene aberration and its clinical significance in breast cancer.

Methods

Breast tumor and adjacent normal tissue of 142 spo

SUBMITTER: Massey S 

PROVIDER: S-EPMC10337982 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature