LC-MS-based serum metabolomics analysis for the screening and monitoring of colorectal cancer.

ABSTRACT:

Background

Colorectal Cancer (CRC) is a prevalent digestive system tumour with significant mortality and recurrence rates. Serum metabolomics, with its high sensitivity and high throughput, has shown potential as a tool to discover biomarkers for clinical screening and monitoring of the CRC patients.

Methods

Serum metabolites of 61 sex and age-matched healthy controls and 62 CRC patients (before and after surgical intervention) were analyzed using a ultra-performance liquid chromatography-high resolution mass spectrometer (UPLC-MS). Statistical methods and pathway enrichment analysis were used to identify potential biomarkers and altered metabolic pathways.

Results

Our analysis revealed a clear distinction in the serum metabolic profile between CRC patients and health

SUBMITTER: Yi Y 

PROVIDER: S-EPMC10338013 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature