Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort.

ABSTRACT:

Background

While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development remains unclear. We aimed to clarify the relationship of accelerated biological age, assessed through two established biological age indicators, telomere length and DNA methylation age, and two novel candidate biological age indicators, to child developmental outcomes, including growth and adiposity, cognition, behavior, lung function and the onset of puberty, among European school-age children participating in the HELIX exposome cohort.

Methods

The study population included up to 1173 children, aged between 5 and 12 years, from study centres in the UK, France,

SUBMITTER: Robinson O 

PROVIDER: S-EPMC10338035 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature