The impact of bone marrow sparing on organs at risk dose for cervical cancer: a Pareto front analysis.

ABSTRACT:

Background and purpose

To quantify the increase in bladder and rectum dose of a bone marrow sparing (BMS) VMAT strategy for primary treatment of locally advanced cervical cancer (LACC).

Materials and methods

Twenty patients with stage IB-IVA cervical cancer were selected for this study. The whole Pelvic Bones (PB) was taken as substitute for bone marrow. For every patient, Pareto-optimal plans were generated to explore the trade-off between rectum, bladder, and PB mean dose. The PB mean dose was decreased in steps of 1 Gy. For each step, the increase in rectum and bladder mean dose was quantified. The increase in mean dose of other OAR compared to no BMS was constrained to 1 Gy.

Results

In total, 931 plans of 19 evaluable patients were analyzed. The average [range] me

SUBMITTER: Kuipers S 

PROVIDER: S-EPMC10338058 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature