Principal component analysis of synaptic density measured with [¹¹C]UCB-J PET in early Alzheimer's disease.

ABSTRACT:

Background

Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer's disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synaptic density using [¹¹C]UCB-J PET and assessed the association between principal components (PC) subject scores with cognitive performance.

Methods

[¹¹C]UCB-J binding was measured in 45 amyloid + participants with AD and 19 amyloid- cognitively normal participants aged 55-85. A validated neuropsychological battery assessed performance across five cognitive domains. PCA was applied to the pooled sample using distribution volume ratios (DVR) standardized (z-scored) by region from 42 bilateral regions of interest (R

SUBMITTER: O'Dell RS 

PROVIDER: S-EPMC10338149 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature