Atypical network topologies enhance the reductive capacity of pathogen thiol antioxidant defense networks.

ABSTRACT: Infectious diseases are a significant health burden for developing countries, particularly with the rise of multidrug resistance. There is an urgent need to elucidate the factors underlying the persistence of pathogens such as Mycobacterium tuberculosis, Plasmodium falciparum and Trypanosoma brucei. In contrast to host cells, these pathogens traverse multiple and varied redox environments during their infectious cycles, including exposure to high levels of host-derived reactive oxygen species. Pathogen antioxidant defenses such as the peroxiredoxin and thioredoxin systems play critical roles in the redox stress tolerance of these cells. However, many of the kinetic rate constants obtained for the pathogen peroxiredoxins are broadly similar to their mammalian homologs and therefore, their c

SUBMITTER: Pillay CS 

PROVIDER: S-EPMC10338151 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature