Seizures regulate the cation-Cl^- cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission.

ABSTRACT:

Background

The balance between the activity of the Na⁺/K⁺/Cl^- cotransporter (NKCC1) that introduces Cl^- into the cell and the K⁺/Cl^- cotransporter (KCC2) that transports Cl^- outside the cell is critical in determining the inhibitory or excitatory outcome of GABA release. Mounting evidence suggests that the impairment of GABAergic inhibitory neurotransmission plays a crucial role in the pathophysiology of epilepsy, both in patients and animal models. Previous studies indicate that decreased KCC2 expression is linked to audiogenic seizures in GASH/Sal hamsters, highlighting that Cl^- imbalance can cause neuronal hyperexcitability. In this study, we aimed to investigate whether the Na⁺/K<

SUBMITTER: Bonet-Fernandez JM 

PROVIDER: S-EPMC10338185 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature