Association of cerebral metabolic rate following therapeutic hypothermia with 18-month neurodevelopmental outcomes after neonatal hypoxic ischemic encephalopathy.

ABSTRACT:

Background

Therapeutic hypothermia (TH) is standard of care for moderate to severe neonatal hypoxic ischemic encephalopathy (HIE) but many survivors still suffer lifelong disabilities and benefits of TH for mild HIE are under active debate. Development of objective diagnostics, with sensitivity to mild HIE, are needed to select, guide, and assess response to treatment. The objective of this study was to determine if cerebral oxygen metabolism (CMRO₂) in the days after TH is associated with 18-month neurodevelopmental outcomes as the first step in evaluating CMRO₂'s potential as a diagnostic for HIE. Secondary objectives were to compare associations with clinical exams and characterise the relationship between CMRO₂ and temperature during TH.

Meth

SUBMITTER: Sutin J 

PROVIDER: S-EPMC10338207 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature