Probiotics formulation and cancer nanovaccines show synergistic effect in immunotherapy and prevention of colon cancer.

ABSTRACT: Probiotics play essential roles in immune modulation. Combining probiotics with cancer vaccines potentially can achieve a synergistic effect. To maximize the efficacy of probiotics, proper probiotics formulation is necessary. Herein, Lactobacillus rhamnosus and Bifidobacterium longum are coated with lipid membrane to achieve the goal of losing less activity and bettering colonization in colon. In the subcutaneous transplanted colon cancer mouse model, probiotics formulation showed potent preventive and therapeutic efficacy, and the efficacy could be further improved by combining with cancer nanovaccines. Probiotics formulation can perform as immune adjuvants to enhance the innate immune response or as in-situ cancer vaccines. In the study of preventing chemical-induced

SUBMITTER: Xu X 

PROVIDER: S-EPMC10338235 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature