AI-designed NMR spectroscopy RF pulses for fast acquisition at high and ultra-high magnetic fields.

ABSTRACT: Nuclear magnetic resonance (NMR) spectroscopy is a powerful high-resolution tool for characterizing biomacromolecular structure, dynamics, and interactions. However, the lengthy longitudinal relaxation of the nuclear spins significantly extends the total experimental time, especially at high and ultra-high magnetic field strengths. Although longitudinal relaxation-enhanced techniques have sped up data acquisition, their application has been limited by the chemical shift dispersion. Here we combined an evolutionary algorithm and artificial intelligence to design ¹H and ¹⁵N radio frequency (RF) pulses with variable phase and amplitude that cover significantly broader bandwidths and allow for rapid data acquisition. We re-engineered the basic transverse relaxation optimi

SUBMITTER: Manu VS 

PROVIDER: S-EPMC10338431 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature