The pharmacological bases for repurposing statins in depression: a review of mechanistic studies.

ABSTRACT: Statins are commonly prescribed medications widely investigated for their potential actions on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may play a role in the treatment of depressive disorders, but only the latter has been systematically assessed. Thus, the physiopathological mechanisms underlying statins' putative antidepressant or depressogenic effects have not been established. This review aims to gather available evidence from mechanistic studies to strengthen the pharmacological basis for repurposing statins in depression. We used a broad, well-validated search strategy over three major databases (Pubmed/MEDLINE, Embase, PsychINFO) to retrieve any mechanistic study investigating statins' effects on depression. The systematic search yielded

SUBMITTER: De Giorgi R 

PROVIDER: S-EPMC10338465 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature