Transcriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates.

ABSTRACT: The storage of lipids as energy in adipose tissue (AT) has been conserved over the course of evolution. However, substantial differences in ATs physiological activities were reported among species. Hence, establishing the mechanisms shaping evolutionarily divergence in ATs transcriptomes could provide a deeper understanding of AT regulation and its roles in obesity-related diseases. While previous studies performed anatomical, physiological and morphological comparisons between ATs across different species, little is currently understood at the molecular phenotypic levels. Here, we characterized transcriptional and lipidomic profiles of available subcutaneous and visceral ATs samples across 15 vertebrate species, spanning more than 300 million years of evolution, including placental mammal

SUBMITTER: Liu P 

PROVIDER: S-EPMC10338492 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature