Cortex-wide topography of 1/f-exponent in Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is a progressive and debilitating brain disorder. Besides the characteristic movement-related symptoms, the disease also causes decline in sensory and cognitive processing. The extent of symptoms and brain-wide projections of neuromodulators such as dopamine suggest that many brain regions are simultaneously affected in PD. To characterise brain-wide disease-related changes in neuronal function, we analysed resting state magnetoencephalogram (MEG) from two groups: PD patients and healthy controls. Besides standard spectral analysis, we quantified the aperiodic components (κ, λ) of the neural activity by fitting a power law κ/f^λ - f is the frequency, κ and λ are the fitting parameters-to the MEG power spectrum and studied its relationship with age and Uni

SUBMITTER: Helson P 

PROVIDER: S-EPMC10338503 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature