External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.

ABSTRACT: The external globus pallidus (GPe) coordinates action-selection through GABAergic projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively to the dorsal striatum, which regulates goal-directed and habitual seeking. However, the role of GPe arky neurons in reward-seeking remains unknown. Here, we identified that a majority of arky neurons target the dorsolateral striatum (DLS). Using fiber photometry, we found that arky activities were higher during random interval (RI; habit) compared to random ratio (RR; goal) operant conditioning. Support vector machine analysis demonstrated that arky neuron activities have sufficient information to distinguish between RR and RI behavior. Genetic ablation of this arky^GPe→DLS circuit facilitated a shift from

SUBMITTER: Baker M 

PROVIDER: S-EPMC10338526 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature