Repeated steroid injection and polyglycolic acid shielding for prevention of refractory esophageal stricture.

ABSTRACT:

Background

Postoperative stricture and refractory stricture are severe adverse events which occur after expansive esophageal endoscopic submucosal dissection (ESD). The aim of this study was to assess the efficacy of steroid injection, polyglycolic acid (PGA) shielding, and of additional steroid injection thereafter for the prevention of refractory esophageal stricture.

Methods

This is a retrospective cohort study of 816 consecutive cases of esophageal ESD performed between 2002 and 2021 at the University of Tokyo Hospital. After 2013, all patients with a diagnosis of superficial esophageal carcinoma covering over 1/2 the esophageal circumference underwent preventive treatment immediately after ESD with either "PGA shielding", "steroid injection", or "steroid injection + PGA

SUBMITTER: Sakaguchi Y 

PROVIDER: S-EPMC10338585 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature