Mid-term symptomatic relief after platelet-rich plasma infiltration in vulvar lichen sclerosus.

ABSTRACT:

Purpose

Vulvar lichen sclerosus (LS) is a chronic, progressive, autoimmune dermatologic condition that causes cutaneous changes accompanied by pruritus and pain. There remains a small population with vulvar LS refractory to topical corticosteroids. Injection of platelet-rich plasma (PRP) has been reported to have positive effects on tissue repair. The aim of this pilot study was to evaluate changes in symptom scores during and after PRP vulvar infiltration.

Methods

Three PRP infiltrations were administered to 28 female postmenopausal patients with biopsy-proved LS with unsatisfactory response to steroid therapy. Change in score according to the Clinical Scoring System for Vulvar Lichen Sclerosus (CSS) was measured on six occasions over the course of a year. We used growth cu

SUBMITTER: Medina Garrido C 

PROVIDER: S-EPMC10338614 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature