Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials.

ABSTRACT: Breast cancer (BrCa) is the leading cause of cancer incidence and mortality in women worldwide. While BrCa treatment has been shown to be highly successful if detected at an early stage, there are few effective strategies to treat metastatic tumours. Hence, metastasis remains the main cause in most of BrCa deaths, highlighting the need for new approaches in this group of patients. Immunotherapy has been gaining attention as a new treatment for BrCa metastasis and the kynurenine pathway (KP) has been suggested as one of the potential targets. The KP is the major biochemical pathway in tryptophan (TRP) metabolism, catabolising TRP to nicotinamide adenine dinucleotide (NAD⁺). The KP has been reported to be elevated under inflammatory conditions such as cancers and that its activity

SUBMITTER: Girithar HN 

PROVIDER: S-EPMC10338682 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature