Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.

ABSTRACT:

Background

Suboptimal performance during neuropsychological testing frequently occurs in multiple sclerosis (MS), leading to unreliable cognitive outcomes. Neurophysiological alterations correlate with MS-related cognitive impairment, but studies have not yet considered performance validity.

Objectives

To investigate neurophysiological markers of cognitive impairment in MS, while explicitly addressing performance validity.

Methods

Magnetoencephalography recordings, neuropsychological assessments, and performance validity testing were obtained from 90 MS outpatients with cognitive complaints. Spectral and resting-state functional connectivity (rsFC) properties were compared between cognitively impaired (CI), cognitively preserved (CP), and suboptimally performing (SUB)

SUBMITTER: Simon S 

PROVIDER: S-EPMC10338702 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature