A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study.

ABSTRACT:

Background

A pro-inflammatory diet has been posited to induce chronic inflammation within the central nervous system (CNS), and multiple sclerosis (MS) is an inflammatory disease of the CNS.

Objective

We examined whether Dietary Inflammatory Index (DII^®)) scores are associated with measures of MS progression and inflammatory activity.

Methods

A cohort with a first clinical diagnosis of CNS demyelination was followed annually (10 years, n = 223). At baseline, 5- and 10-year reviews, DII and energy-adjusted DII (E-DII^TM) scores were calculated (food frequency questionnaire) and assessed as predictors of relapses, annualised change in disability (Expanded Disability Status Scale) and two magnetic resonance imaging measures; fluid-attenuated i

SUBMITTER: Saul AM 

PROVIDER: S-EPMC10338707 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature