Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease.

ABSTRACT:

Background

Gastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry per se but might be associated with lower left striatal dopamine transporter (DAT) binding. The purpose of this study was to further investigate if specific gastrointestinal symptoms associate with monoamine transporter changes in specific striatal or extrastriatal areas.

Methods

Ninety PD patients, who underwent DAT ¹^{2 3} I-FP-CIT SPECT imaging, were assessed using the MDS-Unified Parkinson's Disease Rating Scale part III, Rome III, and Wexner constipation score. DAT binding was calculated from striatal subregions usi

SUBMITTER: Murtomaki K 

PROVIDER: S-EPMC10338780 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature