Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.

ABSTRACT:

Introduction

Sleep abnormalities are highly correlated with neurodevelopmental disorders, such as intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorders (ASD). The severity of behavioral abnormalities is correlated with the presence of sleep abnormalities. Based on previous research, we investigated that Ctnnd2 gene deletion in mice lead to ASD-like behaviors and cognitive defects. Given the importance of sleep in individuals with ASD, this study aimed to determine the effects of chronic sleep restriction (SR) on wild-type (WT) mice and on Ctnnd2 deletion-induced, neurologically related phenotypes in mice.

Method

WT and Ctnnd2 knockout (KO) mice were both subjected to manual SR (5 h per day) for 21 consecutively days separately, then

SUBMITTER: Xu M 

PROVIDER: S-EPMC10338785 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature