Differential expression profiles of plasma exosomal microRNAs in dilated cardiomyopathy with chronic heart failure.

ABSTRACT: As one of the most prevalent heritable cardiovascular diseases, dilated cardiomyopathy (DCM) induces cardiac insufficiency and dysfunction. Although genetic mutation has been identified one of the causes of DCM, the usage of genetic biomarkers such as RNAs for DCM early diagnosis is still being overlooked. In addition, the alternation of RNAs could reflect the progression of the diseases, as an indicator for the prognosis of patients. Therefore, it is beneficial to develop genetic based diagnostic tool for DCM. RNAs are often unstable within circulatory system, leading to the infeasibility for clinical application. Recently discovered exosomal miRNAs have the stability that is then need for diagnostic purpose. Hence, fully understanding of the exosomal miRNA within DCM patients is vital fo

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10339102 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature