Relative and Transport Efficiency-Independent Approach for the Determination of Nanoparticle Size Using Single-Particle ICP-MS.

ABSTRACT: Herein, we introduce the first relative single-particle inductively coupled plasma mass spectrometry (spICP-MS) approach where size calibration is carried out using the target NP itself measured under different instrumental conditions without external dependence on the complex and prone-to-error determination of transport efficiency or mass flux calibrations, in contrast to most spICP-MS approaches. The simple approach proposed allows determining gold nanoparticle (AuNP) sizes, with errors ranging from 0.3 to 3.1% (corroborated by HR-TEM). It has been demonstrated that the changes observed in the single-particle histograms obtained for a suspension of AuNPs under different sensitivity conditions (n = 5) are directly and exclusively related to the mass (size) of the target AuNP itsel

SUBMITTER: Moreira-Alvarez B 

PROVIDER: S-EPMC10339277 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature