[UPLC-Q-TOF-MS/MS combined with network pharmacology for exploring antiinflammatory mechanism of Eurycoma longifolia].

ABSTRACT:

Objective

To explore the mechanisms that mediate the anti-inflammatory activity of Eurycoma longifolia.

Methods

Kunming mouse models of xylene-induced ear swelling and lipopolysaccharide (LPS)-induced acute pneumonia were used to compare the anti- inflammatory activities of aqueous and ethanol extracts of Eurycoma longifolia. UPLC-Q-TOF-MS/MS was used to identify the chemical composition in the ethanol extract of Eurycoma longifolia, based on which the potential antiinflammatory targets of Eurycoma longifolia were screened using the databases including SwissADME, SwissTargetPrediction, and Genecards. The String database was used to generate the protein-protein interaction (PPI) network, and Cytoscape was used for network topology analysis and scre

SUBMITTER: Liu F 

PROVIDER: S-EPMC10339297 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature