Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults.

ABSTRACT: Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions betw

SUBMITTER: Damestani NL 

PROVIDER: S-EPMC10339339 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature