Chorionicity-associated variation in metabolic phenotype of cord blood in twin.

ABSTRACT:

Background

Monochorionic (MC) twins present a higher incidence of unfavorable clinical perinatal outcomes than dichorionic (DC) twins, often in association with placental vascular anastomosis. In this study, we profiled the umbilical cord plasma metabolomes of uncomplicated MC and DC twin pregnancies and related these to several offspring outcomes, previously associated with birthweight.

Methods

Umbilical vein blood samples were collected at birth from 25 pairs of uncomplicated MC twins and 24 pairs of uncomplicated DC twins. The samples were subjected to gas chromatography-mass spectrometry-based metabolomics. 152 metabolites were identified from the cord plasma samples of MC and DC twins. Partial least squares discriminant analysis and pathway analysis were performed to co

SUBMITTER: Liu X 

PROVIDER: S-EPMC10339575 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature