Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism.

ABSTRACT:

Background

Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to explore the mechanisms through which microbiomes affect UA metabolism with the hypothesis that modifying the intestinal microbiota influences the development of hyperuricemia.

Results

We proposed combining an antibiotic strategy with protein-protein interaction analysis to test this hypothesis. The data demonstrated that antibiotics altered the composition of gut microbiota as UA increased, and that the spectrum of the antibiotic was connected to the purine salvage pathway. The antibiotic-elevated UA concentration was dependent on the increase in microbiomes that code for the proteins involved i

SUBMITTER: Liu X 

PROVIDER: S-EPMC10339580 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature