Effects of intraoperative inspired oxygen fraction (FiO₂ 0.3 vs 0.8) on patients undergoing off-pump coronary artery bypass grafting: the CARROT multicenter, cluster-randomized trial.

ABSTRACT:

Background

To maintain adequate oxygenation is of utmost importance in intraoperative care. However, clinical evidence supporting specific oxygen levels in distinct surgical settings is lacking. This study aimed to compare the effects of 30% and 80% oxygen in off-pump coronary artery bypass grafting (OPCAB).

Methods

This multicenter trial was conducted in three tertiary hospitals from August 2019 to August 2021. Patients undergoing OPCAB were cluster-randomized to receive either 30% or 80% oxygen intraoperatively, based on the month when the surgery was performed. The primary endpoint was the length of hospital stay. Intraoperative hemodynamic data were also compared.

Results

A total of 414 patients were cluster-randomized. Length of hospital stay was not different in

SUBMITTER: Nam K 

PROVIDER: S-EPMC10339585 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature