Platelet miRNAs: differential expression in coronary artery disease and associations with course of left ventricular systolic function.

ABSTRACT:

Background

MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%).

Materials and methods

In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vit

SUBMITTER: Goldschmied A 

PROVIDER: S-EPMC10339596 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature