Assessing the performance of European-derived cardiometabolic polygenic risk scores in South-Asians and their interplay with family history.

ABSTRACT:

Background & aims

We aimed to assess the performance of European-derived polygenic risk scores (PRSs) for common metabolic diseases such as coronary artery disease (CAD), obesity, and type 2 diabetes (T2D) in the South Asian (SAS) individuals in the UK Biobank. Additionally, we studied the interaction between PRS and family history (FH) in the same population.

Methods

To calculate the PRS, we used a previously published model derived from the EUR population and applied it to the individuals of SAS ancestry from the UKB study. Each PRS was adjusted according to an individual's genotype location in the principal components (PC) space to derive an ancestry adjusted PRS (aPRS). We calculated the percentiles based on aPRS and stratified individuals into three aPRS categories: low

SUBMITTER: Hassanin E 

PROVIDER: S-EPMC10339617 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature