Stability selection enhances feature selection and enables accurate prediction of gestational age using only five DNA methylation sites.

ABSTRACT:

Background

DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks that can accurately predict chronological age and GA. However, the lack of overlap in predictive CpGs across different epigenetic clocks remains elusive. Our main aim was therefore to identify and characterize CpGs that are stably predictive of GA.

Results

We applied a statistical approach called 'stability selection' to DNAm data from 2138 newborns in the Norwegian Mother, Father, and Child Cohort study. Stability selection combines subsampling with variable selection to restrict the number of false discoveries in the set of selected variables. Twenty-four CpGs wer

SUBMITTER: Haftorn KL 

PROVIDER: S-EPMC10339624 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature