Pharmacogenetics as part of recommended precision medicine for tuberculosis treatment in African populations: Could it be a reality?

ABSTRACT: Globally, tuberculosis (TB) is the second most lethal infectious disease. However, in sub-Saharan Africa, TB has the largest disease burden, with drug-resistant TB increasingly becoming a concern. The social and economic impact of TB should not be overlooked, especially in areas where healthcare systems are overburdened, and resources need to be allocated judiciously. The aim of pharmacogenetics (PGx) is to improve therapeutic response and to minimize adverse drug reactions by selecting the most optimal drug and dosage for the individual patient. Implementation of PGx into routine clinical care has been slow, especially in resource-limited settings, because of perceived high costs relative to uncertain benefit. Given the impact of TB on the disease and disability burden in these regions, a

SUBMITTER: Oelofse C 

PROVIDER: S-EPMC10339705 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature