A click chemistry-based, free radical-initiated delivery system for the capture and release of payloads.

ABSTRACT: Click chemistries are efficient and selective reactions that have been leveraged for multi-stage drug delivery. A multi-stage system allows independent delivery of targeting molecules and drug payloads, but targeting first-phase materials specifically to disease sites remains a challenge. Stimuli-responsive systems are an emerging strategy where common pathophysiological triggers are used to target payloads. Oxidative stress is widely implicated in disease, and we have previously demonstrated that reactive oxygen species (ROS) can crosslink and immobilize polyethylene glycol diacrylate (PEGDA) in tissue mimics. To build on these promising results, we present a two-step, catch-and-release system using azide-DBCO click chemistry and demonstrate the capture and eventual release of a fluoresce

SUBMITTER: DiMartini ET 

PROVIDER: S-EPMC10339776 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature