Modular Design for Proteins Assembling into Antifouling Coatings: Case of Gold Surfaces.

ABSTRACT: We analyze modularity for a B-M-E triblock protein designed to self-assemble into antifouling coatings. Previously, we have shown that the design performs well on silica surfaces when B is taken to be a silica-binding peptide, M is a thermostable trimer domain, and E is the uncharged elastin-like polypeptide (ELP), E = (GSGVP)₄₀. Here, we demonstrate that we can modulate the nature of the substrate on which the coatings form by choosing different solid-binding peptides as binding domain B and that we can modulate antifouling properties by choosing a different hydrophilic block E. Specifically, to arrive at antifouling coatings for gold surfaces, as binding block B we u

SUBMITTER: Zheng C 

PROVIDER: S-EPMC10339784 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature