A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort.

ABSTRACT: Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30 days), sex, and place of birth (N = 962 pairs). Maternal serum cotini

SUBMITTER: Cheslack-Postava K 

PROVIDER: S-EPMC10339819 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature