Cord Blood Hematological Parameters of Fetuses Detected Different Thalassemia Genotypes in the Second Trimester of Pregnancy

ABSTRACT:

Background

Hemoglobinopathies are the most common inherited diseases in humans resulting from impaired globin chain synthesis of hemoglobin. The progression of thalassemia rates is prevented with prenatal screening methods.

Aims

To evaluate the hematological parameters of α- and β-thalassemia and normal fetuses aged 17-25 weeks of gestation.

Study design

A cross-sectional study.

Methods

Pregnant women who underwent cordocentesis in the second trimester because of the risk of having a baby with thalassemia were included in the study. Hematological indices and molecular DNA methods were analyzed from the cord blood samples of 129 women who were 17-25 weeks into pregnancy. The HPLC method was used for Hb fraction analysis. Amplification refractory mutation system,

SUBMITTER: Dundar Yenilmez E 

PROVIDER: S-EPMC10339851 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature