Altered frontal-mediated inhibition and white matter connectivity in pediatric chronic tic disorders.

ABSTRACT: Tics are unique from most movement disorders, in that they are partially suppressible. As part of the inhibitory motor network, the pre-supplementary motor area is engaged in motor control and may be involved in tic physiology. We used dual-site transcranial magnetic stimulation to assess inhibitory connectivity between right pre-supplementary motor area and left primary motor cortex, which has previously been demonstrated in healthy adults. We also used diffusion tensor imaging to investigate white matter connectivity in children with chronic tics. Twelve children with chronic tic disorder and fourteen typically developing controls underwent MRI with diffusion tensor imaging indices analysis followed by single and paired-pulse transcranial magnetic stimulation with conditioning pulse over

SUBMITTER: Bruce AB 

PROVIDER: S-EPMC10340132 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature