Sterol Regulation of Development and 20-Hydroxyecdysone Biosynthetic and Signaling Genes in Drosophila melanogaster.

ABSTRACT: Ecdysteroids are crucial in regulating the growth and development of insects. In the fruit fly Drosophila melanogaster, both C₂₇ and C₂₈ ecdysteroids have been identified. While the biosynthetic pathway of the C₂₇ ecdysteroid 20-hydroxyecdysone (20E) from cholesterol is relatively well understood, the biosynthetic pathway of C₂₈ ecdysteroids from C₂₈ or C₂₉ dietary sterols remains unknown. In this study, we found that different dietary sterols (including the C₂₇ sterols cholesterol and 7-dehydrocholesterol, the C₂₈ sterols brassicasterol, campesterol, and ergosterol, and the C₂₉ sterols β-sitosterol, α-spinasterol, and stigmasterol) differentially affected the expression of 20E biosynt

SUBMITTER: Wen D 

PROVIDER: S-EPMC10340181 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature