The Role of Targeted Therapy in the Multi-Disciplinary Approach to Colorectal Liver Metastasis.

ABSTRACT: Colorectal cancer (CRC) is the second most common cause of cancer-related mortality in the United States. Among newly diagnosed patients with CRC, 20% will present with metastatic disease and another 25% will develop metastases. The surgical resection of the primary tumor and metastatic disease sites confers the best chance at long-term survival. Unfortunately, many patients will recur after resection or present with unresectable disease. As such, metastatic CRC is commonly treated with a combination of surgery, systemic therapy, and/or liver-directed therapies. Despite best efforts, 5-year survival for unresectable metastatic CRC is only about 20%. CRC is a heterogeneous disease and the underlying genetic differences inform behavior, treatment strategy, and prognosis. Given the limitation

SUBMITTER: Ruff SM 

PROVIDER: S-EPMC10340452 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature