Leveraging Gene Redundancy to Find New Histone Drivers in Cancer.

ABSTRACT: Histones play a critical role in chromatin function but are susceptible to mutagenesis. In fact, numerous mutations have been observed in several cancer types, and a few of them have been associated with carcinogenesis. Histones are peculiar, as they are encoded by a large number of genes, and the majority of them are clustered in three regions of the human genome. In addition, their replication and expression are tightly regulated in a cell. Understanding the etiology of cancer mutations in histone genes is impeded by their functional and sequence redundancy, their unusual genomic organization, and the necessity to be rapidly produced during cell division. Here, we collected a large data set of histone gene mutations in cancer and used it to investigate their distribution over 96 human hi

SUBMITTER: Ostroverkhova D 

PROVIDER: S-EPMC10340511 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature