Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling.

ABSTRACT: Type II diabetes affects over 530 million individuals worldwide and contributes to a host of neurological pathologies. Uncontrolled high blood glucose (hyperglycemia) is a major factor in diabetic pathology, and glucose regulation is a common goal for maintenance in patients. We have found that the neuronal growth factor progranulin protects against hyperglycemic stress in neurons, and although its mechanism of action is uncertain, our findings identified Glycogen Synthase Kinase 3β (GSK3β) as being potentially involved in its effects. In this study, we treated mouse primary cortical neurons exposed to high-glucose conditions with progranulin and a selective pharmacological inhibitor of GSK3β before assessing neuronal health and function. Whole-cell and mitochondrial viability were both im

SUBMITTER: Dedert C 

PROVIDER: S-EPMC10340575 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature