Microbial Communities in Gynecological Cancers and Their Association with Tumor Somatic Variation.

ABSTRACT: There are strong correlations between the microbiome and human disease, including cancer. However, very little is known about potential mechanisms associated with malignant transformation in microbiome-associated gynecological cancer, except for HPV-induced cervical cancer. Our hypothesis is that differences in bacterial communities in upper genital tract epithelium may lead to selection of specific genomic variation at the cellular level of these tissues that may predispose to their malignant transformation. We first assessed differences in the taxonomic composition of microbial communities and genomic variation between gynecologic cancers and normal samples. Then, we performed a correlation analysis to assess whether differences in microbial communities selected for specific single nucle

SUBMITTER: Gonzalez-Bosquet J 

PROVIDER: S-EPMC10340580 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature