Trajectory of Spike-Specific B Cells Elicited by Two Doses of BNT162b2 mRNA Vaccine.

ABSTRACT: The mRNA vaccines for SARS-CoV-2 have demonstrated efficacy and immunogenicity in the real-world setting. However, most of the research on vaccine immunogenicity has been centered on characterizing the antibody response, with limited exploration into the persistence of spike-specific memory B cells. Here we monitored the durability of the memory B cell response up to 9 months post-vaccination, and characterized the trajectory of spike-specific B cell phenotypes in healthy individuals who received two doses of the BNT162b2 vaccine. To profile the spike-specific B cell response, we applied the tSNE and Cytotree automated approaches. Spike-specific IgA⁺ and IgG⁺ plasmablasts and IgA⁺ activated cells were observed 7 days after the second dose and disappeared 3

SUBMITTER: Ciabattini A 

PROVIDER: S-EPMC10340653 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature