Targeting Transcription Factor YY1 for Cancer Treatment: Current Strategies and Future Directions.

ABSTRACT: Cancer represents a significant and persistent global health burden, with its impact underscored by its prevalence and devastating consequences. Whereas numerous oncogenes could contribute to cancer development, a group of transcription factors (TFs) are overactive in the majority of tumors. Targeting these TFs may also combat the downstream oncogenes activated by the TFs, making them attractive potential targets for effective antitumor therapeutic strategy. One such TF is yin yang 1 (YY1), which plays crucial roles in the development and progression of various tumors. In preclinical studies, YY1 inhibition has shown efficacy in inhibiting tumor growth, promoting apoptosis, and sensitizing tumor cells to chemotherapy. Recent studies have also revealed the potential of combining YY1 inhibit

SUBMITTER: Hosea R 

PROVIDER: S-EPMC10340792 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature