Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex.

ABSTRACT: During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species. PTN signaling includes PTPRZ1, ALK, and NRP-1 receptors, which are implicated in cell differentiation, migration, and proliferation. However, its involvement in human cerebellar development has not been described so far. Therefore, we investigated whether PTN and its receptors were expressed in the human cerebellar cortex during fetal and early neonatal development. The expression profile of PTN and its receptors was analyzed using an immunohistochemical method. PTN, PTPRZ1, and NRP-1 were expressed from week 17 to the postnatal stage, with variable expr

SUBMITTER: Santana-Bejarano MB 

PROVIDER: S-EPMC10341181 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature