Methods for Evaluating the Efficacy of Medical Castration: A Systematic Review.

ABSTRACT: Measuring serum testosterone determination during medical castration is recommended by prostate cancer (PCa) guidelines to assess its efficacy and define castration resistance. It has been suggested that other biochemical compounds, such as free testosterone or luteinising hormone (LH), could also assess castration efficacy. We aimed to analyse the current evidence for serum biochemical compounds that could be appropriate candidates for evaluating medical castration efficacy. A systematic review was conducted after two investigators independently searched the literature in the PubMed, Cochrane Library, and EMBASE databases published between January 1980 and February 2023. Their searches used the medical subject headings 'prostatic neoplasms', 'testosterone and androgen antagonists', 'gonad

SUBMITTER: Aguilar A 

PROVIDER: S-EPMC10341338 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature