Targeting Metabolic Vulnerabilities in Epstein-Barr Virus-Driven Proliferative Diseases.

ABSTRACT: The metabolism of cancer cells and Epstein-Barr virus (EBV) infected cells have remarkable similarities. Cancer cells frequently reprogram metabolic pathways to augment their ability to support abnormal rates of proliferation and promote intra-organismal spread through metastatic invasion. On the other hand, EBV is also capable of manipulating host cell metabolism to enable sustained growth and division during latency as well as intra- and inter-individual transmission during lytic replication. It comes as no surprise that EBV, the first oncogenic virus to be described in humans, is a key driver for a significant fraction of human malignancies in the world (~1% of all cancers), both in terms of new diagnoses and attributable deaths each year. Understanding the contributions of metabolic pa

SUBMITTER: Leung NYT 

PROVIDER: S-EPMC10341354 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature