Prevalence, Concordance, and Heritability of Vitreomacular Interface Abnormalities in a Twin Study.

ABSTRACT:

Purpose

The relative importance of genetic factors in common vitreomacular interface (VMI) abnormalities is unknown. The aim of this classical twin study is to determine the prevalence case wise concordance between monozygotic and dizygotic twin pairs, and heritability of common VMI abnormalities, including epiretinal membrane (ERM), posterior vitreous detachment (PVD), vitreomacular adhesion (VMA), vitreomacular traction (VMT), lamellar macular holes (LMHs), and full-thickness macular holes (FTMHs).

Methods

This is a single-center, cross-sectional classical twin study of 3406 TwinsUK participants over the age of 40 years who underwent spectral domain macular optical coherence tomography (SD-OCT) scans which were graded for signs of VMI abnormalities. Case wise concordance w

SUBMITTER: Jarrar ZA 

PROVIDER: S-EPMC10341355 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature