APOE Locus-Associated Mitochondrial Function and Its Implication in Alzheimer's Disease and Aging.

ABSTRACT: The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its association with Alzheimer's disease (AD) and longevity. This genetic association appears across multiple genes in the APOE locus. Despite the apparent differences between AD and longevity, both conditions share a commonality of aging-related changes in mitochondrial function. This commonality is likely due to accumulative biological effects partly exerted by the APOE locus. In this study, we investigated changes in mitochondrial structure/function-related markers using oxidative stress-induced human cellular models and postmortem brains (PMBs) from individuals with AD and normal controls. Our results reveal a range of expressional alterations, either upregulated or downregulate

SUBMITTER: Lee EG 

PROVIDER: S-EPMC10341489 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature