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Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review.


ABSTRACT: Ischemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia's effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focused on nanoparticle-based treatments for ischemic stroke in animal models. We summarized the effectiveness of nanotherapies in these models, considering multiple factors such as their anti-inflammatory, antioxidant, and angiogenetic properties, as well as their safety and biodistribution. We conclude that the application of nanomedicines may reduce infarct size and improve neurological function post-stroke without causing significant organ toxicity.

SUBMITTER: Ruscu M 

PROVIDER: S-EPMC10341504 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review.

Ruscu Mihai M   Cercel Andreea A   Kilic Ertugrul E   Catalin Bogdan B   Gresita Andrei A   Hermann Dirk M DM   Albu Carmen Valeria CV   Popa-Wagner Aurel A  

International journal of molecular sciences 20230628 13


Ischemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia's effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focus  ...[more]

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